TGR5 agonist 2

• UNSPSC Description:

  TGR5 agonist 2 (compound 19) is a potent TGR5 agonist with an EC50 value of 0.27 µM[1].

• Target Antigen:

  G protein-coupled Bile Acid Receptor 1

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/tgr5-agonist-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]12C[C@H]([C@@]3([C@]([H])([C@@H](CCCC(NCCS(=O)(O[Na])=O)=O)C)CC[C@]3([C@@]1([C@@H]([C@@H]([C@@]4(C[C@@H](CC[C@@]42C)O)[H])CC)O)[H])[H])[H])C

• Molecular Weight:

  563.77

• References & Citations:

  [1]Luxenburger A, et al. The discovery of 12β-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists. Eur J Med Chem. 2023 Mar 15;250:115143.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported