LSD1-UM-109

• UNSPSC Description:

  LSD1-UM-109 is a ighly potent and reversible LSD1 inhibitor with an IC50 of 3.1 nM. LSD1-UM-109 inhibits cell growth with IC50 values of 0.6 nM in the MV4;11 acute leukemia cell line and 1.1 nM in the H1417 small-cell lung cancer cell line[1].

• Target Antigen:

  Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-um-109.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(N=C1)C2=C1C=C(C=C2)C3=C(C4=CC=C(C#N)C(F)=C4)C5=C(N(CC6(C)CCNCC6)C=C5)C=N3

• Molecular Weight:

  478.56

• References & Citations:

  [1]Canhui Zheng, et al. Discovery of Pyrrolo[2,3- c]pyridines as Potent and Reversible LSD1 Inhibitors. ACS Med Chem Lett. 2023 Sep 21;14(10):1389-1395.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2252446-26-5