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LSD1-UM-109

CAT: 0804-HY-149595Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149595Size:1 Each
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Description
LSD1-UM-109 is a ighly potent and reversible LSD1 inhibitor with an IC50 of 3.1 nM. LSD1-UM-109 inhibits cell growth with IC50 values of 0.6 nM in the MV4;11 acute leukemia cell line and 1.1 nM in the H1417 small-cell lung cancer cell line[1].
CAS Number
2252446-26-5
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsd1-um-109.html
Solubility
10 mM in DMSO
Smiles
CN(N=C1)C2=C1C=C(C=C2)C3=C(C4=CC=C(C#N)C(F)=C4)C5=C(N(CC6(C)CCNCC6)C=C5)C=N3
Molecular Formula
C29H27FN6
Molecular Weight
478.56
References & Citations
[1]Canhui Zheng, et al. Discovery of Pyrrolo[2,3- c]pyridines as Potent and Reversible LSD1 Inhibitors. ACS Med Chem Lett. 2023 Sep 21;14 (10) :1389-1395.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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