UM-242

• Description :

  UM-242 is a STING inhibitor, with an EC50 of 1.70 μM in THP1-Dual cells expressing wild-type STING. UM-242 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6 and reducing IFNβ secretion. UM-242 can be used for the study of STING-dependent inflammatory and neurological diseases[1].

• UNSPSC :

  12352005

• Target :

  IFNAR; Interleukin Related; STING

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Smiles :

  O=C(C1=NOC(C2=CC(F)=CC=C2F)=N1)N[C@H](C3=NC4=CC=CC=C4N3)CCNC(C5=CC=C([N+]([O-])=O)O5)=N

• Molecular Formula :

  C24H18F2N8O5

• Molecular Weight :

  536.45

• References & Citations :

  [1]Barasa L, et al. Nitrofuran-Based STING Inhibitors. ACS Omega. 2025 Sep 4;10 (36) :41693-41706.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported