TWIK-1/TREK-1-IN-2

TWIK-1/TREK-1-IN-2

• CAS Number: 1440532-32-0
• UNSPSC Description: TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant[1].
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/twik-1-trek-1-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H](COC1=CC=C(C(F)(F)F)C=C1)CN(CC2)CCC2N3CCCCC3
• Molecular Weight: 386.45
• References & Citations: [1]Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported