PARP-1/2-IN-2

• UNSPSC Description:

  PARP-1/2-IN-2-IN-1 (Compound 12e) is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively). PARP-1/2-IN-2 inhibits DNA damage repair, promotes cell cycle arrest and apoptosis. PARP-1/2-IN-2 inhibits the growth of TNBC cells and TNBC xenograft tumor[1].

• Target Antigen:

  Apoptosis; CDK; PARP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/parp-1-2-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC(C1=CC=CC2=C1N=C(NC(C3=CC(C(N4CCC(NC5=NC=C(I)C=N5)CC4)=O)=CC=C3)=O)N2)=O

• Molecular Weight:

  610.41

• References & Citations:

  [1]Zhang L, et al. Discovery of a novel dual-target inhibitor of CDK12 and PARP1 that induces synthetic lethality for treatment of triple-negative breast cancer. Eur J Med Chem. 2023 Jul 16;259:115648.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3052304-23-8