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Amifampridine (phosphate)

CAT: 0804-HY-14946ASize: 1 EachDry Ice: NoHazardous: No
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Description
Amifampridine (3,4-Diaminopyridine) phosphate is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine phosphate is efficacy in the reversal of BoNT/A intoxication. Amifampridine phosphate increases transmitter release from neuromuscular junctions (NMJs). Amifampridine phosphate can be used for Lambert-Eaton myasthenic syndrome (LEMS) research[1][2][3].
CAS Number
446254-47-3
Product Name Alternative
3,4-Diaminopyridine (phosphate)
UNSPSC
12352005
Hazard Statement
H300-H311-H315-H319-H330-H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amifampridine-phosphate.html
Solubility
10 mM in DMSO
Smiles
NC1=C(N)C=CN=C1.O=P(O)(O)O
Molecular Formula
C5H10N3O4P
Molecular Weight
207.12
Precautions
P260-P261-P264-P270-P271-P280-P284-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501
References & Citations
[1]Maarten J Titulaer, et al. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 2011 Dec;10 (12) :1098-107.|[2]T L Harris, et al. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication. Chem Commun (Camb) . 2016 Mar 18;52 (22) :4187-90.|[3]Ojala KS, et al. A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. J Biol Chem. 2021 Jan-Jun;296:100302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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