Rilmenidine (phosphate)

CAT: 0804-HY-100490B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100490B-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1][2][3].
CAS Number
[85409-38-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rilmenidine-phosphate.html
Purity
99.48
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 83.33 mg/mL (ultrasonic)
Smiles
O=P(O)(O)O.C1(NC(C2CC2)C3CC3)=NCCO1
Molecular Formula
C10H19N2O5P
Molecular Weight
278.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13 (6 Pt 2) :106S-111S.|[2]Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.|[3]Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19 (11) :2144-2153.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

Related Products

CatalogName
HY-100490-01Rilmenidine
HY-100490A-01Rilmenidine (hemifumarate)
HY-100490RRilmenidine (Standard)
HY-100490S-01Rilmenidine-d4
HY-100490AR-01Rilmenidine (hemifumarate) (Standard)
HY-Y1322-01Triphenyl phosphate
HY-B1067BAntazoline (phosphate)
HY-122385Dabequin (phosphate)
HY-14946AAmifampridine (phosphate)
HY-10250-01Triciribine phosphate

Alternative Products

CatalogName
C17979-01Rilmenidine Phosphate
A14256-1Rilmenidine Phosphate 1mg
A14256-100Rilmenidine Phosphate 100mg
A14256-500Rilmenidine Phosphate 500mg
A14256-10Rilmenidine Phosphate 10mg
RM-R091300-01Rilmenidine Dihydrogen Phosphate
A14256-5Rilmenidine Phosphate 5mg
A14256-25Rilmenidine Phosphate 25mg
A14256-50Rilmenidine Phosphate 50mg
TRC-R509712-50MGRilmenidine-SIL Phosphate-d4

Popular Products