Rilmenidine (phosphate)

Rilmenidine (phosphate)

• CAS Number: 85409-38-7
• UNSPSC Description: Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1][2][3].
• Target Antigen: Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;GPCR/G Protein;Neuronal Signaling
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/rilmenidine-phosphate.html
• Purity: 98.0
• Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 83.33 mg/mL (ultrasonic)
• Smiles: O=P(O)(O)O.C1(NC(C2CC2)C3CC3)=NCCO1
• Molecular Weight: 278.24
• References & Citations: [1]Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S.|[2]Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.|[3]Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched