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Amifampridine

CAT: 0804-HY-14946-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-14946-01Size:10 g
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Description
Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research[1][2][3].
CAS Number
54-96-6
Product Name Alternative
3,4-Diaminopyridine
UNSPSC
12352005
Hazard Statement
H300+H330, H311, H319
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Amifampridine.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C(N)C=CN=C1
Molecular Formula
C5H7N3
Molecular Weight
109.13
Precautions
H300+H330, H311, H319
References & Citations
[1]Maarten J Titulaer, et al. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 2011 Dec;10 (12) :1098-107.|[2]T L Harris, et al. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication. Chem Commun (Camb) . 2016 Mar 18;52 (22) :4187-90.|[3]Ojala KS, et al. A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. J Biol Chem. 2021 Jan-Jun;296:100302.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
Launched

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