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Clindamycin phosphate

CAT: 0804-HY-B1064-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1064-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis[1][2][3]. Clindamycin phosphate has no cytotoxicity. Combined with platelet rich fibrin (PRF), PRF-Clindamycin phosphate enhances antimicrobial properties[4].
CAS Number
24729-96-2
Product Name Alternative
Clindamycin 2-phosphate; U-28508
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/clindamycin-phosphate.html
Purity
99.46
Solubility
H2O : 175 mg/mL (ultrasonic)
Smiles
CCC[C@H]1CN(C)[C@H](C(N[C@@]([H])([C@@]2([H])O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O)[C@@H](Cl)C)=O)C1
Molecular Formula
C18H34ClN2O8PS
Molecular Weight
504.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Li H, et al. Clindamycin hydrochloride and clindamycin phosphate: two drugs or one? A retrospective analysis of a spontaneous reporting system. Eur J Clin Pharmacol. 2017 Feb;73 (2) :251-253.|[2]Hayashi N, et al. Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed-dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, investigator-blind, parallel-group study. J Dermatol. 2018 Aug;45 (8) :951-962.|[3]A. Dupre, et al. Proof of concept study of a novel bioadhesive clindamycin phosphate 2% vaginal gel to treat bacterial vaginosis. Clin. Exp. Obstet. Gynecol. 2020, 47 (4), 516–518|[4]Egle K, et al.Injectable Platelet-Rich Fibrin as a Drug Carrier Increases the Antibacterial Susceptibility of Antibiotic-Clindamycin Phosphate. Int J Mol Sci. 2022 Jul 3;23 (13) :7407
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
EBioMedicine. 2022 Apr;78:103943.|Tissue Cell. 2025 Jan 25:93:102759.|bioRxiv. 2024 Jan 18.|bioRxiv. 2024 May 10.

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