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Amifampridine (Standard)

CAT: 0804-HY-14946R-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14946R-01Size:25 mg
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Description
Amifampridine (Standard) is the analytical standard of Amifampridine. This product is intended for research and analytical applications. Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research[1][2][3].
CAS Number
54-96-6
Product Name Alternative
3,4-Diaminopyridine (Standard)
UNSPSC
12352005
Target
Potassium Channel; Reference Standards
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amifampridine-standard.html
Smiles
NC1=C(N)C=CN=C1
Molecular Formula
C5H7N3
Molecular Weight
109.13
References & Citations
[1]Maarten J Titulaer, et al. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 2011 Dec;10 (12) :1098-107.|[2]T L Harris, et al. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication. Chem Commun (Camb) . 2016 Mar 18;52 (22) :4187-90.|[3]Ojala KS, et al. A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. J Biol Chem. 2021 Jan-Jun;296:100302.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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