Etoposide phosphate

• Description :

  Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.

• Product Name Alternative :

  BMY-40481

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H350, H361, H412

• Target :

  Apoptosis; Autophagy; Bacterial; Topoisomerase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/etoposide-phosphate.html

• Purity :

  99.44

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  O=C1OC[C@]2([H])[C@H](O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO4)O3)O[C@@H]4C)O)O)C5=C(C=C6OCOC6=C5)[C@@H](C7=CC(OC)=C(OP(O)(O)=O)C(OC)=C7)[C@]21[H]

• Molecular Formula :

  C29H33O16P

• Molecular Weight :

  668.54

• Precautions :

  H302, H350, H361, H412

• References & Citations :

  [1]Witterland AH, et al. Etoposide phosphate, the water soluble prodrug of etoposide. Pharm World Sci. 1996 Oct;18 (5) :163-70.|[2]Bregman CL, et al. Etoposide- and BMY-40481-induced sensory neuropathy in mice.Toxicol Pathol. 1994 Sep-Oct;22 (5) :528-35.|[3]Cui D, et al. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.Cell Rep. 2020 Jan 14;30 (2) :497-509.e4.|[4]SUMMARY OF PRODUCT CHARACTERISTICS

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  Topo II

• CAS Number :

  [117091-64-2]