PI3Kα-IN-12

PI3Kα-IN-12

• CAS Number: 2966861-50-5
• UNSPSC Description: PI3Kα-IN-12 (compound 13) is a highly selective PI3Kα inhibitor (IC50: 1.2 nM). PI3Kα-IN-12 inhibits HCT-116 and U87-MG with IC50s values of 0.83 and 1.25 μM, respectively. PI3Kα-IN-12 (40 mg/kg; IP) causes tumor regression in a U87-MG cell line xenograft mouse model[1].
• Target Antigen: PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/pi3kα-in-12.html
• Solubility: 10 mM in DMSO
• Smiles: S=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)SCC(N6CCN(S(=O)(C)=O)CC6)=O
• Molecular Weight: 726.84
• References & Citations: [1]Tang J, et al. Design and Synthesis of 1,3,5-Triazines or Pyrimidines Containing Dithiocarbamate Moiety as PI3Kα Selective Inhibitors. ACS Med Chem Lett. 2023 Aug 9;14(9):1266-1274..
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported