PI3Kα-IN-12

CAT: 0931-T78804-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T78804-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

PI3K

Related Pathways

PI3K/Akt/mTOR signaling

Bioactivity

PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values of 0.83 and 1.25 μM, respectively. Intraperitoneal administration of PI3Kα-IN-12 (40 mg/kg) induces tumor regression in a mouse xenograft model bearing U87-MG cells [1].

Molecular Formula

C28H36F2N10O5S3

Molecular Weight

726.84

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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