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D3R ligand 1

CAT: 0804-HY-149337Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149337Size:1 Each
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Description
D3R ligand 1 (compound 23b) is a potent and selective ligand of dopamine receptor D3R (Ki=66 nM), containing a THPB template. D3R ligand 1 is also an antagonist for both G-protein- and β-arrestin-based signaling[1].
CAS Number
2983777-91-7
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d3r-ligand-1.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C=C(C2=C1)CCN3[C@H]2CC4=CC=C(C(OCCOCC)=C4C3)O)OCCCCCC
Molecular Formula
C27H37NO5
Molecular Weight
455.59
References & Citations
[1]Namballa HK, et al. Discovery of Selective Dopamine Receptor Ligands Derived from (-) -Stepholidine via C-3 Alkoxylation and C-3/C-9 Dialkoxylation. J Med Chem. 2023 Jul 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D3 Receptor

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