COX-2-IN-31

CAT: 0804-HY-149270Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-149270Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM) . COX-2-IN-31 also inhibits transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity[1].

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-in-31.html

Solubility

10 mM in DMSO

Smiles

NC1=C(C=NN1C2=CC=C(C=C2)S(N)(=O)=O)C(N/N=C/C3=CC=C(C=C3)O)=O

Molecular Formula

C17H16N6O4S

Molecular Weight

400.41

References & Citations

[1]Ragab MA, et al. 4- (5-Amino-pyrazol-1-yl) benzene sulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Mar 15; 250:115180.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-1; COX-2

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COX-2-IN-31

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