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COX-2-IN-30

CAT: 0804-HY-149269Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149269Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC50=49 nM for COX-2, 10.4 μM for COX-1) and 5-LOX (IC50=2.4 μM) . COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss Ki values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect[1].
CAS Number
1160498-08-7
UNSPSC
12352005
Target
Carbonic Anhydrase; COX; LOX-1
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-30.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(N(N=C1)C2=CC=C(C=C2)S(N)(=O)=O)N)N/N=C/C3=CC=CC=C3
Molecular Formula
C17H16N6O3S
Molecular Weight
384.41
References & Citations
[1]Ragab MA, et al. 4- (5-Amino-pyrazol-1-yl) benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Mar 15;250:115180.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX; CA XII; COX-1; COX-2

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