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PI3Kδ-IN-12

CAT: 0804-HY-149235Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149235Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI3Kδ-IN-12 (compound 13) is a PI3Kδ inhibitor (pIC50 = 5.8), with pKi values of 8.0/6.5/6.4/6.7 for PI3Kδ/γ/β/α, respectively. PI3Kδ-IN-12 can be used in the study of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) [1].
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pi3kδ-in-12.html
Solubility
10 mM in DMSO
Smiles
NC(C1=C2NC(N(C2=NC(C3=CC(O)=CC=C3)=N1)CCC4=CC=C(C(Cl)=C4)Cl)=O)=O
Molecular Formula
C20H15Cl2N5O3
Molecular Weight
444.27
References & Citations
[1]Mazzucato R, et al. Application of an "inhalation by design" approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors. Eur J Med Chem. 2023 Jun 5;254:115331.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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