PLK1-IN-6

PLK1-IN-6

• UNSPSC Description: PLK1-IN-6 is a potent and selective PLK1 inhibitor, with an IC50 of 0.45 nM. PLK1-IN-6 shows significant anti-proliferative activities against cancer cells[1].
• Target Antigen: Epigenetic Reader Domain; Polo-like Kinase (PLK)
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/plk1-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: CC[C@@H]1C(N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C5=NOC(CN6CCNCC6)=N5)OC)C)=O
• Molecular Weight: 547.65
• References & Citations: [1]Li Z, et, al. Design, synthesis, and biological evaluation of novel dihydropteridone derivatives possessing oxadiazoles moiety as potent inhibitors of PLK1. Eur J Med Chem. 2023 May 5;251:115242.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported