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PLK1-IN-6

CAT: 0804-HY-149100Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149100Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLK1-IN-6 is a potent and selective PLK1 inhibitor, with an IC50 of 0.45 nM. PLK1-IN-6 shows significant anti-proliferative activities against cancer cells[1].
UNSPSC
12352005
Target
Epigenetic Reader Domain; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plk1-in-6.html
Solubility
10 mM in DMSO
Smiles
CC[C@@H]1C(N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C5=NOC(CN6CCNCC6)=N5)OC)C)=O
Molecular Formula
C28H37N9O3
Molecular Weight
547.65
References & Citations
[1]Li Z, et, al. Design, synthesis, and biological evaluation of novel dihydropteridone derivatives possessing oxadiazoles moiety as potent inhibitors of PLK1. Eur J Med Chem. 2023 May 5;251:115242.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; PLK1; PLK2; PLK3

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