PLK1-IN-4

• Description:

  PLK1-IN-4 is a potent and selective PLK1 inhibitor with IC50 apoptosis. PLK1-IN-4 can be used for researching hepatocellular carcinoma[1].

• UNSPSC:

  12352005

• Target:

  Polo-like Kinase (PLK)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/plk1-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C=C2C(CCN2C(CN(C)C)=O)=C1)NC3=NC=C(C(NC4=C(SC=C4)C(OC)=O)=N3)C(F)(F)F

• Molecular Formula:

  C24H25F3N6O4S

• Molecular Weight:

  550.55

• References & Citations:

  [1]Deng Z, et al. Discovery of methyl 3- ((2- ((1- (dimethylglycyl) -5-methoxyindolin-6-yl) amino) -5- (trifluoro-methyl) pyrimidin-4-yl) amino) thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma. Eur J Med Chem. 2020;206:112697.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2622273-55-4]