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PLK1-IN-9

CAT: 0804-HY-W276819Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W276819Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model[1].
CAS Number
893772-67-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plk1-in-9.html
Solubility
10 mM in DMSO
Smiles
CN1C2=C(N=C3C1=NC(NC3=O)=O)C=C(C(F)(F)F)C=C2
Molecular Formula
C12H7F3N4O2
Molecular Weight
296.20
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kin K, et al., Pharmaceutical composition for preventing or treating cancer, containing activation inhibitor of plk1 as active ingredient. WO2020111325.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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