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OY-101

CAT: 0804-HY-149053Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149053Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OY-101 is an orally active, potent and specific P-glycoprotein (P-gp) inhibitor. OY-101 can sensitize drug-resistant tumors and effectively reverse tumor multidrug resistance. OY-101 is improvements in water-solubility, cytotoxicity, and reversal activity compared to Tetrandrine (HY-13764) [1].
CAS Number
[41183-02-2]
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oy-101.html
Solubility
10 mM in DMSO
Smiles
CN1C(CC2=CC=C(OC)C(OCC3=CC=CC=C3)=C2)C4=C(C=C(OC)C(OC)=C4)CC1
Molecular Formula
C27H31NO4
Molecular Weight
433.54
References & Citations
[1]Zeng R, et al. Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy. J Med Chem. 2023 Mar 23;66 (6) :4086-4105.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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