Tubulin polymerization-IN-26
CAT:
804-HY-149020
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Tubulin polymerization-IN-26
- CAS Number: 2490291-68-2
- UNSPSC Description: Tubulin polymerization-IN-26 (compound 12h) can inhibit the polymerization of microtubulin by binding to the colchicine binding site of microtubulin with an IC50 value of 4.64 μM. Tubulin polymerization-IN-26 can induce apoptosis and inhibit cell metastasis or migration, and can be used as a potential compound for lung cancer research[1].
- Target Antigen: Apoptosis; Microtubule/Tubulin
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-26.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(NC1=CC=CC=C1C2=NC3=CC(C)=CC=C3N2)/C=C/C4=CC=CC=C4OCC
- Molecular Weight: 397.47
- References & Citations: [1]Kavitha Donthiboina，et al. Synthesis and biological evaluation of substituted N-(2-(1H-benzo[d]imidazol-2-yl)phenyl)cinnamides as tubulin polymerization inhibitors. Bioorg Chem. 2020 Oct;103:104191.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported