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FGFR-IN-10

CAT: 0804-HY-148597Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-148597Size:1 Each
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Description
FGFR-IN-10 is an orally active inhibitor of FGFR and Cytochrome P450 (CYPs) . FGFR-IN-10 inhibits wide type and V564F mutant FGFR2 with IC50s of 104.1 nM and 43.6 nM, respectively. FGFR-IN-10 also inhibits CYPs with IC50s of 3.33 μM (CYP2C9), 18.75 μM (CYP2C19), 4.34 μM (CYP2CD6), and 0.69 μM (CYP3A4), respectively[1].
CAS Number
2847092-41-3
UNSPSC
12352005
Target
Cytochrome P450; FGFR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr-in-10.html
Solubility
10 mM in DMSO
Smiles
FC(C=C1C2=CN=C(N=C2N3C[C@H](N([C@@H](C3)C)C(C=C)=O)C)NC4=CN(N=C4)C)=C(C=C1)OC5=NC=CC(C)=N5
Molecular Formula
C28H30FN9O2
Molecular Weight
543.60
References & Citations
[1]Zhu Wei, et al. Heterocyclic compound serving as FGFR inhibitor and application thereof: World Intellectual Property Organization, WO2022206939. 2022-10-06.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2; CYP3

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sc-136988FGFR-4 (A-10)
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sc-136988 PEFGFR-4 (A-10) PE
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sc-136988 AF488FGFR-4 (A-10) Alexa Fluor® 488
sc-136988 AF680FGFR-4 (A-10) Alexa Fluor® 680
sc-136988 AF790FGFR-4 (A-10) Alexa Fluor® 790
sc-136988 AF647FGFR-4 (A-10) Alexa Fluor® 647
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