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FGFR-IN-20

CAT: 0804-HY-172923Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172923Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glu-IN-1 (compound AF1) is a covalent and selective FGFR2 inhibitor with an IC50 of 1.6 μM. Glu-IN-1 covalently modifies Glu489 in FGFR2[1].
UNSPSC
12352211
Target
FGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CNC(C1=CC=C2C(N=C(N2CCCCCCCCCCNC(C3N=C3C4=CC=CC=C4)=O)C5=CC(C)=C(C(C)=C5)O)=C1)=O
Molecular Formula
C36H43N5O3
Molecular Weight
593.76
References & Citations
[1]Wu X, et al. Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads. J Am Chem Soc. 2025 May 7;147 (18) :15469-15481.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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