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FGFR-IN-19

CAT: 0804-HY-172922Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172922Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Arg-IN-1 is a selective Arginine (Arg) -targeting covalent inhibitor with IC50s of 9.7 nM and 30.4 nM for FGFR2 and FGFR3, respectively. Arg-IN-1 has the potential to avoid FGFR1/4-targeted toxicity as well as conquer acquired on-target resistance, potential for FGFR-targeting cancer therapy[1].
UNSPSC
12352211
Target
FGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COCCNC1=NC(NC2=NNC(C3=CC=CC=C3)=C2)=NC(NC4CC5(C4)CCN(CC5)C(CN6C=C(N=N6)COC7=CC=C(C=C7)C(C(O)O)=O)=O)=N1
Molecular Formula
C36H42N12O6
Molecular Weight
738.80
References & Citations
[1]Wu X, et al. Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads. J Am Chem Soc. 2025 May 7; 147 (18) :15469-15481.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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