AChE-IN-19

• Description :

  AChE-IN-19 (compound A15) is a highly potent AChE inhibitor with an IC50 value of 0.56 μM, also inhibits Aβ aggregation. AChE-IN-19 has potent neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE-IN-19 can be used for researching Alzheimer's disease[1].

• CAS Number :

  [2742707-36-2]

• UNSPSC :

  12352005

• Target :

  Amyloid-β; Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ache-in-19.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(OC1=CC(OC)=C2CCC(C3=CC(OC)=C(OC)C(OC)=C3)OC2=C1)/C=C/C4=CC=C(N(C)C)C=C4

• Molecular Formula :

  C30H33NO7

• Molecular Weight :

  519.59

• References & Citations :

  [1]Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE