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AChE-IN-19

CAT: 0804-HY-147938Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147938Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE-IN-19 (compound A15) is a highly potent AChE inhibitor with an IC50 value of 0.56 μM, also inhibits Aβ aggregation. AChE-IN-19 has potent neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE-IN-19 can be used for researching Alzheimer's disease[1].
CAS Number
[2742707-36-2]
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-19.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1=CC(OC)=C2CCC(C3=CC(OC)=C(OC)C(OC)=C3)OC2=C1)/C=C/C4=CC=C(N(C)C)C=C4
Molecular Formula
C30H33NO7
Molecular Weight
519.59
References & Citations
[1]Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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