AChE-IN-19

• Description:

  AChE-IN-19 (compound A15) is a highly potent AChE inhibitor with an IC50 value of 0.56 μM, also inhibits Aβ aggregation. AChE-IN-19 has potent neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE-IN-19 can be used for researching Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ache-in-19.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC1=CC(OC)=C2CCC(C3=CC(OC)=C(OC)C(OC)=C3)OC2=C1)/C=C/C4=CC=C(N(C)C)C=C4

• Molecular Formula:

  C30H33NO7

• Molecular Weight:

  519.59

• References & Citations:

  [1]Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE

• CAS Number:

  [2742707-36-2]