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PIM1-IN-7

CAT: 0804-HY-147921Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147921Size:1 Each
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Description
PIM1-IN-7 (compound 6c) is a potent PIM-1 inhibitor, with an IC50 of 0.67 μM. PIM1-IN-7 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC50 values of 42.9 and 7.68 μM, respectively[1].
CAS Number
2439168-72-4
UNSPSC
12352005
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pim1-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2N=C(C)C=C(C)N2N=C1NC3=CC=CC=C3)NC4=C(C)C=CC=C4C
Molecular Formula
C23H23N5O
Molecular Weight
385.46
References & Citations
[1]Philoppes JN, et al. New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics. Bioorg Chem. 2020 Jul;100:103944.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1

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