PIM1-IN-8

• Description:

  PIM1-IN-8 is a PIM1/p65 pathway inhibitor. PIM1-IN-8 suppresses the expression of α-SMA and collagen I in activated fibroblasts and blocks TGF-β induced migration. PIM1-IN-8 alleviates pulmonary fibrosis in a Bleomycin (BLM) (HY-17565A) -induced pulmonary fibrosis mice model. PIM1-IN-8 can be used for the study of idiopathic pulmonary fibrosis (IPF) [1].

• UNSPSC:

  12352005

• Target:

  Interleukin Related; NF-κB; Pim

• Related Pathways:

  Immunology/Inflammation; JAK/STAT Signaling; NF-κB

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(NC1=CC(C(C)=O)=C(O)C=C1OC)C2=CC=CC(C)=C2

• Molecular Formula:

  C17H17NO4

• Molecular Weight:

  299.32

• References & Citations:

  [1]Zhang F, et al. Novel paeonol derivatives: Design, synthesis, and their activity in relieving idiopathic pulmonary fibrosis via the PIM1/p65 pathway. Bioorg Chem. 2025 Aug;163:108731.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported