PIM1-IN-4

• Description:

  PIM1-IN-4 (Compound 8) is a potent inhibitor of PIM1. PIM1-IN-4 reveals strong inhibition of five other enzymes, i.e., SGK-1, PKA, CaMK-1, GSK3β, and MSK1. PIM1-IN-4 has the potential for the research of cancer diseases[1].

• UNSPSC:

  12352005

• Target:

  Pim

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pim1-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  BrC1=CC=C(C2=C1)NC3=C2C4=C([N]5=C3N[N]6=C(C7=CC=C(C=[N]7[Cu]65(Cl)Cl)CN8CCOCC8)C)C=CC=C4

• Molecular Formula:

  C27H25BrCl2CuN6O

• Molecular Weight:

  663.88

• References & Citations:

  [1]Wittmann C, et al. Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper (II) Markedly Changes the Kinase Inhibitory Profile. J Med Chem. 2022 Feb 10;65 (3) :2238-2261.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PIM1

• CAS Number:

  [2762767-48-4]