PIM1-IN-2

• Description:

  PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds[1].

• UNSPSC:

  12352005

• Target:

  Pim

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pim1-in-2.html

• Purity:

  99.0

• Solubility:

  DMSO : 20 mg/mL (ultrasonic; warming)

• Smiles:

  NC1=NC=CC(C2=CC3=C(C4=CC=C(Cl)C=C4)ON=C3C=C2)=N1

• Molecular Formula:

  C17H11ClN4O

• Molecular Weight:

  322.75

• References & Citations:

  [1]Pierce AC, Jacobs M, Stuver-Moody C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J Med Chem. 2008 Mar 27;51 (6) :1972-5.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PIM1

• CAS Number:

  [477845-12-8]