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CDK6/PIM1-IN-1

CAT: 0804-HY-142696Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-142696Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK6/PIM1-IN-1 is a potent and balanced dual CDK6/PIM1 inhibitor with IC50 values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 inhibits CDK4 (IC50=3.6 nM) . CDK6/PIM1-IN-1 significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity[1].
CAS Number
2677026-14-9
UNSPSC
12352005
Target
Apoptosis; CDK; Pim
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk6-pim1-in-1.html
Solubility
10 mM in DMSO
Smiles
FC1=CN=C(NC2=NC=C(N3CCNCC3)C=C2)N=C1C4=CC=C5N=CC(N(CC)CC)=NC5=C4
Molecular Formula
C25H28FN9
Molecular Weight
473.55
References & Citations
[1]Kai Yuan, et al. Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2022 Jan 13;65 (1) :857-875.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK12; CDK13; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK9; PIM1; PIM2; PIM3

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GTR19185957-01CDK6/PIM1-IN-1
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T201591-01CDK6-IN-1
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A19392-50PIM1-IN-1 50mg
A19392-25PIM1-IN-1 25mg
A19392-5PIM1-IN-1 5mg
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