CDK6/PIM1-IN-1

CDK6/PIM1-IN-1

• CAS Number: 2677026-14-9
• UNSPSC Description: CDK6/PIM1-IN-1 is a potent and balanced dual CDK6/PIM1 inhibitor with IC50?values of 39 and 88 nM, respectively.?CDK6/PIM1-IN-1 inhibits CDK4 (IC50=3.6 nM). CDK6/PIM1-IN-1 significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity[1].
• Target Antigen: Apoptosis; CDK; Pim
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;JAK/STAT Signaling
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk6-pim1-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CN=C(NC2=NC=C(N3CCNCC3)C=C2)N=C1C4=CC=C5N=CC(N(CC)CC)=NC5=C4
• Molecular Weight: 473.55
• References & Citations: [1]Kai Yuan, et al. Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2022 Jan 13;65(1):857-875.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported