PIM1-IN-3

• Description:

  PIM1-IN-3 (Compound HL8) is a potent inhibitor of PIM1. PIM1-IN-3 shows selective inhibition for the PIM-1 enzyme. PIM1-IN-3 induces apoptosis efficiently in Colo320 cells. PIM1-IN-3 has the potential for the research of cancer diseases[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Pim

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; JAK/STAT Signaling

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pim1-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C/C (C1=CC=C (C=N1) CN2CCOCC2) =N\N=C (C3=C4C5=CC (Br) =CC=C5N3) /NC6=C4C=CC=C6

• Molecular Formula:

  C27H25BrN6O

• Molecular Weight:

  529.43

• References & Citations:

  [1]Wittmann C, et al. Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper (II) Markedly Changes the Kinase Inhibitory Profile. J Med Chem. 2022 Feb 10;65 (3) :2238-2261.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PIM1

• CAS Number:

  2762767-56-4