PIM1-IN-3

CAT: 0804-HY-143897Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-143897Size:1 Each
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Description
PIM1-IN-3 (Compound HL8) is a potent inhibitor of PIM1. PIM1-IN-3 shows selective inhibition for the PIM-1 enzyme. PIM1-IN-3 induces apoptosis efficiently in Colo320 cells. PIM1-IN-3 has the potential for the research of cancer diseases[1].
CAS Number
[2762767-56-4]
UNSPSC
12352005
Target
Apoptosis; Pim
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pim1-in-3.html
Solubility
10 mM in DMSO
Smiles
C/C(C1=CC=C(C=N1)CN2CCOCC2)=N\N=C(C3=C4C5=CC(Br)=CC=C5N3)/NC6=C4C=CC=C6
Molecular Formula
C27H25BrN6O
Molecular Weight
529.43
References & Citations
[1]Wittmann C, et al. Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper (II) Markedly Changes the Kinase Inhibitory Profile. J Med Chem. 2022 Feb 10;65 (3) :2238-2261.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1

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