COX-2-IN-22

• UNSPSC Description:

  COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 µM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 µM, respectively. COX-2-IN-22 can cross BBB[1].

• Target Antigen:

  Beta-secretase; Cholinesterase (ChE); COX

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cox-2-in-22.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C=C(/C=C/C2=CC(OC)=CC(OC)=C2)C3=C(C4=C(OC(C5=CC(OC)=CC(OC)=C5)=C4)C=C3)O1

• Molecular Weight:

  484.50

• References & Citations:

  [1]Agbo EN, et al. Synthesis of furocoumarin-stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer's disease. Bioorg Chem. 2020 Aug;101:103997.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2447589-08-2