B-Raf IN 9

B-Raf IN 9

• CAS Number: 2477725-18-9
• UNSPSC Description: B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM[1].
• Target Antigen: Apoptosis; Raf
• Type: Reference compound
• Related Pathways: Apoptosis;MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/b-raf-in-9.html
• Solubility: 10 mM in DMSO
• Smiles: S=C(NC1=CC=CC=C1)NC2=CC=C(C(CC3)=NN(C4=CC=CC=C4)C3=O)C=C2
• Molecular Weight: 400.50
• References & Citations: [1]Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported