ALK-IN-22

• Description :

  ALK-IN-22 (compound I-24) is a potent ALK inhibitor with IC50 values of 2.3, 3.7 and 2.9 nM for ALK, ALKL1196M and ALKG1202R, respectively. ALK-IN-22 down-regulated the phosphorylation of ALK and its downstream proteins. ALK-IN-22 induces apoptosis. ALK-IN-22 can be used for tumor research[1].

• UNSPSC :

  12352005

• Target :

  Anaplastic lymphoma kinase (ALK) ; Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/alk-in-22.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=C(C)NC2=C1C=CC(NC3=NC=C(Cl)C(NC4=CC=CC=C4C(NC)=O)=N3)=C2)N(C)C

• Molecular Formula :

  C24H24ClN7O2

• Molecular Weight :

  477.95

• References & Citations :

  [1]Thacker PS, et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2468219-09-0]