ALK-IN-6

• Description:

  ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively[1].

• UNSPSC:

  12352005

• Target:

  Anaplastic lymphoma kinase (ALK)

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CN=C (NC2=C (OC ([2H]) ([2H]) [2H]) C=C (C3CCNCC3) C (C) =C2) N=C1NC4=CC=CC=C4S (=O) (C (C) C) =O

• Molecular Formula:

  C26H29D3ClN5O3S

• Molecular Weight:

  533.10

• References & Citations:

  [1]Das D, et al. Design, synthesis of orally bioavailable novel anaplastic lymphoma kinase (ALK) inhibitor diphenylaminopyrimidine analogs and efficacy study on NCI-H2228 xenografts mice model. Bioorg Med Chem Lett. 2019 Jun 15;29 (12) :1514-1517.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2055821-33-3