ALK-IN-5

• Description:

  ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM[1].

• UNSPSC:

  12352005

• Target:

  Anaplastic lymphoma kinase (ALK)

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/alk-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (C1=CN (C2=NNC (C) =C2) C3=NC (O[C@H] (C4=NC=C (F) C=C4) C) =CC=C31) N5C[C@H] (C) OCC5

• Molecular Formula:

  C24H25FN6O3

• Molecular Weight:

  464.49

• References & Citations:

  [1]Fushimi M, et al. Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors. J Med Chem. 2019 May 23;62 (10) :4915-4935.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2351929-66-1