ALK-IN-31

CAT: 0804-HY-173493Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-173493Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor (IC50: 1135 nM) . ALK-IN-31 exhibits excellent antiproliferative activity against lung cancer H2228 cells with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation in the G0/G1 phase by affecting mitochondrial function. ALK-IN-31 exerts its anti-tumor effect by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. ALK-IN-31 can be used in the study of non-small cell lung cancer (NSCLC) [1].
CAS Number
[3043840-25-8]
UNSPSC
12352005
Target
Akt; Anaplastic lymphoma kinase (ALK) ; Apoptosis; mTOR
Related Pathways
Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1CCCCC1)NC2=CC=CC=C2NC3=C(CSCC4)C4=NC(NC(C=C5CCC6)=CC=C5C6=O)=N3
Molecular Formula
C30H33N5O2S
Molecular Weight
527.68
References & Citations
[1]Wang R, et al. Novel ALK inhibitors containing DAAP fragments: Rational drug design and anti-tumor activity research. Bioorg Chem. 2025 Jun 15;160:108416.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-151281ALK5-IN-31
HY-151155ALK-IN-23
HY-13464-01ALK-IN-1
HY-128569ALK-IN-5
HY-128596ALK-IN-6
HY-108230ALK-IN-12
HY-168513ALK-IN-29
HY-131244ALK-IN-9
HY-156432-01ALK-IN-26
HY-12973ALK-IN-13

Alternative Products

CatalogName
MF-0062539-01ALK-IN-31
CR223-0.5mlALK
A1425-100Anti-ALK Antibody (ALK/1503)

Popular Products