ALK-IN-12

CAT: 0804-HY-108230Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-108230Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALK-IN-12 is a potent and orally active ALK inhibitor with an IC50 of 0.18 nM. ALK-IN-12 also inhibits IGF1R and InsR (IC50=20.3 and 90.6 nM) . Antitumor activities[1].
CAS Number
[1197958-53-4]
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk-in-12.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4P(C)(C)=O)=N3)C(OC)=C2)CC1
Molecular Formula
C24H30ClN6O2P
Molecular Weight
500.96
References & Citations
[1]Huang WS, et al. Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase. J Med Chem. 2016;59 (10) :4948-4964.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
MBS5799211ALK-IN-12
sc-398791ALK (F-12)
sc-398791 FITCALK (F-12) FITC
sc-398791 HRPALK (F-12) HRP
sc-398791 PEALK (F-12) PE
sc-398791 PALK (F-12) P
sc-398791 ACALK (F-12) AC
sc-398791 AF680ALK (F-12) Alexa Fluor® 680
sc-398791 AF647ALK (F-12) Alexa Fluor® 647
sc-398791 AF594ALK (F-12) Alexa Fluor® 594

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