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HDHODH-IN-9

CAT: 0804-HY-147788Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147788Size:1 Each
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Description
HDHODH-IN-9 (Compound 3k) is a potent inhibitor of hDHODH with an IC50 of 0.34 μM. hDHODH-IN-9 demonstrates high cytotoxic activity against MCF-7 and A375 cells and good selectivity. hDHODH-IN-9 has the potential for the research of cancer diseases[1].
CAS Number
133676-47-8
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdhodh-in-9.html
Solubility
10 mM in DMSO
Smiles
CCCCOC1=CC=C(C=C1OC)C2=NC3=CC=CC=C3C(C(O)=O)=C2
Molecular Formula
C21H21NO4
Molecular Weight
351.40
References & Citations
[1]Petrović MM, et al. Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes: Synthesis, cytotoxicity, lipophilicity and molecular docking studies. Bioorg Chem. 2020;105:104373.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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