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HDHODH-IN-2

CAT: 0804-HY-135654Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135654Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].
CAS Number
183946-00-1
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hdhodh-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)/C(C#N)=C(C3CC3)\O
Molecular Formula
C19H16N2O2
Molecular Weight
304.34
References & Citations
[1]Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12 (5) :2982-93.|[2]Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9 (2) :e87960.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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