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HDHODH-IN-8

CAT: 0804-HY-145261Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145261Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential for the research of tumor disease, especially lymphoma[1].
CAS Number
2757405-31-3
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hdhodh-in-8.html
Solubility
10 mM in DMSO
Smiles
FC1=C(NC(/C(C#N)=C(O)/C)=O)C=C(O[C@H](C(F)(F)F)C)C(C(NC2=C(F)C=CC=C2F)=O)=C1
Molecular Formula
C21H15F6N3O4
Molecular Weight
487.35
References & Citations
[1]Li C, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment. J Med Chem. 2021;64 (24) :18175-18192.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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