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COX-2-IN-17

CAT: 0804-HY-147748Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147748Size:1 Each
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Description
COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase[1].
CAS Number
2411390-10-6
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-17.html
Solubility
10 mM in DMSO
Smiles
N[C@@H](CC1=CN(C2=NC(Cl)=NC(N3CCCCC3)=N2)C4=CC=CC=C14)C(OC)=O
Molecular Formula
C20H23ClN6O2
Molecular Weight
414.89
References & Citations
[1]Kumari P, et al. Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats. Bioorg Med Chem. 2020 Jan 15;28 (2) :115246.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

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