BPH-1218

• Description:

  BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC50 of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent[1][2][3].

• UNSPSC:

  12352005

• Target:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/bph-1218.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(O)(C(P(O)(O)=O)C[N+]1=CN(CCCCCCCCCC)C=C1)[O-]

• Molecular Formula:

  C15H30N2O6P2

• Molecular Weight:

  396.36

• References & Citations:

  [1]Melissa A Sleda, wt al. The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection. mBio. 2022 Oct 26;13 (5) :e0196622.|[2]Na Shang, et al. Squalene Synthase As a Target for Chagas Disease Therapeutics. PLoS Pathog. 2014 May 1;10 (5) :e1004114.|[3]M J Barry, et al. Benign Prostatic Hyperplasia Specific Health Status Measures in Clinical Research: How Much Change in the American Urological Association Symptom Index and the Benign Prostatic Hyperplasia Impact Index is Perceptible to Patients? J Urol. 1995 Nov;154 (5) :1770-4.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1426824-36-3]