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BPH-1218

CAT: 0804-HY-135625Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-135625Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC50 of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent[1][2][3].
CAS Number
[1426824-36-3]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bph-1218.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(C(P(O)(O)=O)C[N+]1=CN(CCCCCCCCCC)C=C1)[O-]
Molecular Formula
C15H30N2O6P2
Molecular Weight
396.36
References & Citations
[1]Melissa A Sleda, wt al. The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection. mBio. 2022 Oct 26;13 (5) :e0196622.|[2]Na Shang, et al. Squalene Synthase As a Target for Chagas Disease Therapeutics. PLoS Pathog. 2014 May 1;10 (5) :e1004114.|[3]M J Barry, et al. Benign Prostatic Hyperplasia Specific Health Status Measures in Clinical Research: How Much Change in the American Urological Association Symptom Index and the Benign Prostatic Hyperplasia Impact Index is Perceptible to Patients? J Urol. 1995 Nov;154 (5) :1770-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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