Cyclic GMP (Standard)

• Description:

  Cyclic GMP (Standard) is the analytical standard of Cyclic GMP (HY-113469) . This product is intended for research and analytical applications. Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs) . Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses[1][2][3][4].

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite; Reference Standards

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Inflammation/Immunology; Cardiovascular Disease

• Purity:

  99.54

• Smiles:

  O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4(O)=O

• Molecular Formula:

  C10H12N5O7P

• Molecular Weight:

  345.21

• References & Citations:

  [1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339 (6121) :826-30.|[2]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503 (7477) :530-4.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, sealed storage, away from light and moisture

• Scientific Category:

  Reference Standards

• CAS Number:

  [7665-99-8]