Noncatechol agonist-1

CAT: 0804-HY-W664041Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W664041Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Noncatechol agonist-1 (19) is a Noncatechol agonist with full efficacy at both D1R-G protein and D1R-β-arrestin2 pathways, with pEC50 values of 8.41 for D1R-mediated cAMP production and 7.7 for β-arrestin2 recruitment, respectively[1].
CAS Number
[1609580-99-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC1=C(C2=C(C)C(NC(N2C)=O)=O)C=CC(OC3=C4C(OC=C4)=CC=N3)=C1
Molecular Formula
C20H17N3O4
Molecular Weight
363.37
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Ashley N Nilson, et al. Functionally Selective Dopamine D1 Receptor Endocytosis and Signaling by Catechol and Noncatechol Agonists. Biochemistry. 2025 Apr 1;64 (7) :1572-1588.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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