KRAS inhibitor-14

KRAS inhibitor-14

• CAS Number: 2230873-78-4
• UNSPSC Description: KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC50 of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC50s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
• Target Antigen: Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/kras-inhibitor-14.html
• Solubility: 10 mM in DMSO
• Smiles: C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=CC(Cl)=C4Cl)=C(C3=NS2)F)Cl)=O
• Molecular Weight: 486.77
• References & Citations: [1]Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported