KRAS inhibitor-15
CAT:
804-HY-146545
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
KRAS inhibitor-15
- CAS Number: 2230873-75-1
- UNSPSC Description: KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
- Target Antigen: Ras
- Type: Reference compound
- Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/kras-inhibitor-15.html
- Solubility: 10 mM in DMSO
- Smiles: C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(N)=CC=C4Cl)=C(C3=NS2)F)Cl)=O
- Molecular Weight: 451.34
- References & Citations: [1]Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported