KRAS inhibitor-21
CAT:
804-HY-151288
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
KRAS inhibitor-21
- CAS Number: 2411786-50-8
- UNSPSC Description: KRAS inhibitor-21 (22b) is a KRAS G12C inhibitor with an IC50 value of [1].
- Target Antigen: Ras
- Type: Reference compound
- Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/kras-inhibitor-21.html
- Solubility: 10 mM in DMSO
- Smiles: C[C@H]1CN(C(C=C)=O)CCN1C2=NC(OC[C@H]3N(CCC3)C)=NC4=C2C[C@@H](C)[C@H](C5=CC(O)=CC6=C5C=CC=C6)C4
- Molecular Weight: 555.71
- References & Citations: [1]Kargbo RB, et al. Small-Molecule Inhibitor of the Oncogenic KRASG12C Mutant for the Treatment of Currently Incurable Cancer. ACS Med Chem Lett. 2022 Apr 20;13(5):767-769.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported