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KRAS inhibitor-18

CAT: 0931-T62784-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62784-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2230873-66-0
Target
Others, Kras, Ras
Related Pathways
Others, GPCR/G Protein, MAPK
Bioactivity
KRAS inhibitor-18 (compound 3-10) is a potent inhibitor of KRAS G12C (IC50: 4.74 μM) and exhibited p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50s of 66.4 μM and 11.1 μM, respectively. KRAS inhibitor-18 has potential for pancreatic, colorectal, and lung cancer studies.
Smiles
FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(F)C=C(F)C(O)=C4
Molecular Formula
C20H15ClF3N3O2S
Molecular Weight
453.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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